Histopathological Effect of Annona Muricata Fruit Extract on Methyl nitrosourea -Induced Mammary Gland Carcinoma in Female Albino Mice

The Annona muricata (Family-Annonaceae) fruit contain annonaceous acetogenins which have an effect on cancer cell as reported in many research studies. This study was aimed to evaluate the of methanolic extract (MFEAM) breast histology and invasive MNU-induced mice. Fifty female albino mice were divided into five groups (of ten each): control; cancer; + 200 mg/kg, 300 mg/kg 500 mg/kg. indicates that ductal carcnoma (IDC) developed group. control group showed normal duct structure. -treated lower (DCIS) compared with untreated We concluded (MFEAM), improved histological changes cancer-induced MNU. Also reduced proliferative epitheal MNU most effective dose present methanol extracts derived from potentially exhibit antitumor activity. group,